Source:http://www.reactome.org/biopax/48887BiochemicalReaction2596
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Authored: de Bono, B, 2004-08-04 09:17:50,
C3b:Bb is naturally labile with a half-life of ~90 s; association of the complex with properdin extends the half-life to ~30 min. (Medicus et al. 1976). Properdin is found in the blood as a mixture of multivalent oligomers: 30% dimers, 45% trimers, 10% tetramers, and 15% higher oligomers. Monomers associate with one another in a head-to-tail arrangement, producing closed circular structures (Smith et al. 1984). These features suggest that the properdin oligomer associated with a C3b:Bb complex on a surface such as a cell membrane can facilitate recruitment of additional C3b:Bb complexes to the site (Farries et al. 1988; Hourcade 2006).,
Reviewed: D'Eustachio, P, 2006-07-03 21:35:13
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Properdin stabilizes C3b:Bb bound to cell surfaces
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