Source:http://www.reactome.org/biopax/48887BiochemicalReaction259
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Authored: D'Eustachio, P, 2008-11-29 15:41:00,
Edited: D'Eustachio, P, 2008-11-29 15:41:00,
GARS (cytosolic glycyl tRNA synthetase) catalyzes the reaction of glycine, tRNA(Gly), and ATP to form Gly tRNA(Gly), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a dimer. Cytosolic and mitochondrial glycyl tRNA synthetase enzymes are both encoded by the same gene; the cytosolic protein lacks an aminoterminal 54 residue sequence found in the mitochondrial protein. Mutations in <I>GARS</I> are associated with Charcot Marie Tooth disease and distal spinal muscular atrophy, two diseases characterized by axonal dysfunction (Antonellis et al. 2006),
Reviewed: Antonellis, A, 2008-12-02 16:58:45
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glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
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6.1.1.14
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