Source:http://www.reactome.org/biopax/48887BiochemicalReaction2575
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Authored: de Bono, B, 2005-08-16 10:54:15,
Edited: Shamovsky, V, 2011-08-12,
Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002).,
Reviewed: Gay, NJ, 2006-04-24 16:48:17,
Reviewed: Gillespie, ME, 2010-11-30
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| biopax3:xref |
http://identifiers.org/pubmed/11287640,
http://identifiers.org/pubmed/12138165,
http://identifiers.org/pubmed/12140561,
http://identifiers.org/pubmed/18070982,
http://identifiers.org/pubmed/8837778,
urn:biopax:UnificationXref:REACTOME DATABASE ID_166363,
urn:biopax:UnificationXref:REACTOME_REACT_6856_7
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TRAF6 binds to hp- IRAK1
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