Source:http://www.reactome.org/biopax/48887BiochemicalReaction2572
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Authored: de Bono, B, 2005-08-16 10:54:15,
Edited: Shamovsky, V, 2011-08-12,
First, IRAK-1 is phosphorylated at Thr209. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK-1.,
Reviewed: Gay, NJ, 2006-04-24 16:48:17,
Reviewed: Gillespie, ME, 2010-11-30
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First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
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2.7.11
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