Source:http://www.reactome.org/biopax/48887BiochemicalReaction2541
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Authored: Shamovsky, V, 2010-06-01,
Edited: Shamovsky, V, 2010-11-15,
NF-kappa-B essential modulator (NEMO, also known as IKKG abbreviated from Inhibitor of nuclear factor kappa-B kinase subunit gamma) is the regulatory subunit of the IKK complex which phosphorylates inhibitors of NF-kappa-B leading to dissociation of the inhibitor/NF-kappa-B complex. NEMO binds to K63-pUb chains (Ea et al. 2006; Wu et al. 2006), linking K63-pUb-hp-IRAK1 with the IKK complex. Models of IL-1R dependent activation of NF-kappaB suggest that the polyubiquitination of both TRAF6 and IRAK1 within a TRAF6:IRAK1 complex and their subsequent interactions with the TAK1 complex and IKK complex respectively brings these complexes into proximity, facilitating the TAK1-catalyzed activation of IKK (Moynagh, 2008).,
Reviewed: Gillespie, ME, 2010-10-29
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http://identifiers.org/pubmed/16547522,
http://identifiers.org/pubmed/16603398,
http://identifiers.org/pubmed/18180283,
http://identifiers.org/pubmed/18347055,
http://identifiers.org/pubmed/19022706,
urn:biopax:UnificationXref:REACTOME DATABASE ID_975119,
urn:biopax:UnificationXref:REACTOME_REACT_25072_1
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NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
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