Source:http://www.reactome.org/biopax/48887BiochemicalReaction2512
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Authored: Shamovsky, V, 2010-06-01,
Edited: Shamovsky, V, 2011-08-12,
Reviewed: Gillespie, ME, 2010-11-30,
The mechanism of TBK1 or IKKi{epsilon} activation by TIKAM1 is unclear. It was suggested that these protein kinases undergo autophosphorylation. The most recent studies showed that phosphorylation and the activation of TBK1/ IKKi are catalyzed by a distinct protein kinase (Clark et al. 2009). Other studies demonstrated an essential role of TRAF3 in the activation of TBK1 (Hacker et al 2006).<p>It was also shown that the ubiquitin like domain (ULD) of TBK1 and IKK-i, a regulatory component, is involved in the control of kinase activation, substrate presentation and downstream signaling.
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Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3|TLR4 followed by their phosphorylation
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