Source:http://www.reactome.org/biopax/48887BiochemicalReaction2484
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Authored: Shamovsky, V, 2009-12-16,
Edited: Shamovsky, V, 2011-08-12,
NFkB is a family of transcription factors that play pivotal roles in immune, inflammatory, and antiapoptotic responses. The five NF-kB/Rel family members, p65 (RelA), RelB, c-Rel, p50/p105 (NF-kB1) and p52/p100 (NF-kB2), exist in unstimulated cells as homo or heterodimers; the most common heterodimer is p65/p50. NF-kB is sequestered in the cytosol of unstimulated cells through the interactions with a class of inhibitor proteins called IkBs, which mask the nuclear localization signal of NF-kB and prevent its nuclear translocation. Various stimuli induce the activation of the IkB kinase (IKK) complex, which then phosphorylates IkBs. The phosphorylated IkBs are ubiquitinated and then degraded through the proteasome-mediated pathway. The degradation of IkBs releases NF-kB to translocate into nucleus and induces the expression of various genes.,
Reviewed: D'Eustachio, P, 2011-12-07,
Reviewed: Upton, JW, Mocarski, ES, 2012--0-2-
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Released NFkB complex is transported to nucleus
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