Linked Life Data

48887BiochemicalReaction2470

Source:http://www.reactome.org/biopax/48887BiochemicalReaction2470

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Authored: Shamovsky, V, 2010-08-25, Edited: Shamovsky, V, 2011-08-12, Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002)., IRAK-2 has two TRAF6 binding motifs that are responsible for initiating TRAF6 signaling transduction (Ye H et al 2002). IRAK2 point mutants with mutated TRAF6-binding motifs abrogate NFkB activation and are incapable to stimulate TRAF6 ubiquitination (Keating SE et al 2007)., Reviewed: Gillespie, ME, 2011-02-10, Reviewed: Li, L, 2011-08-04
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TRAF6 binds to hp- IRAK1 or p-IRAK2
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