Linked Life Data

48887BiochemicalReaction2465

Source:http://www.reactome.org/biopax/48887BiochemicalReaction2465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
Authored: Shamovsky, V, 2010-10-06, Edited: Shamovsky, V, 2011-08-12, IRAK2 has been implicated in IL1R and TLR signaling by the observation that IRAK2 can associate with MyD88 and Mal (Muzio et al. 1997). Like IRAK1, IRAK2 is activated downstream of IRAK4 (Kawagoe et al. 2008). It has been suggested that IRAK1 activates IRAK2 (Wesche et al. 1999) but IRAK2 phosphorylation is observed in IRAK1â??/â?? mouse macrophages while IRAK4 deficiency abrogates IRAK2 phosphorylation (Kawagoe et al. 2008), suggesting that activated IRAK4 phosphorylates IRAK2 as it does IRAK1. IL6 production in response to IL1beta is impaired in embryonic fibroblasts from IRAK1 or IRAK2 knockout mice and abrogated in IRAK1/2 dual knockouts (Kawagoe et al. 2007) suggesting that IRAK1 and IRAK2 are both involved in IL1R signaling downstream of IRAK4., MYD88 recruits unphosphorylated, inactive IRAK1 to the IL1 receptor complex., Reviewed: Gillespie, ME, 2011-02-10, Reviewed: Li, L, 2011-08-04
biopax3:xref
biopax3:dataSource
biopax3:displayName
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
biopax3:left
biopax3:participantStoichio...
biopax3:right