Source:http://www.reactome.org/biopax/48887BiochemicalReaction2450
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Authored: Akkerman, JW, 2009-06-03,
EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function.,
Edited: Jupe, S, 2010-09-01,
Reviewed: Heemskerk, JW, 2010-09-01
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Activation of EPACs by cAMP
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