Source:http://www.reactome.org/biopax/48887BiochemicalReaction2438
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Authored: de Bono, B, 2007-07-08 12:58:15,
CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.,
Reviewed: Trowsdale, J, 2007-08-06 19:33:04
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MHC Class I interacts with CD160
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