Source:http://www.reactome.org/biopax/48887BiochemicalReaction2431
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Authored: de Bono, B, 2007-07-08 12:58:15,
Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be expressed on telencepahlic neurons.<p><p>VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4).<p><p>To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change.<p><p>Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.,
Reviewed: Trowsdale, J, 2007-08-06 19:33:04
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ICAMs 1-4 bind to Integrin LFA-1
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