Source:http://www.reactome.org/biopax/48887BiochemicalReaction2341
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Authored: May, B, 2011-01-19,
Edited: May, B, 2011-01-19,
In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).,
Reviewed: Wienands, J, 2012-02-11
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Oligomerization of STIM1
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