Source:http://www.reactome.org/biopax/48887BiochemicalReaction2328
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Authored: Garapati, P V, 2008-12-16 11:12:19,
Edited: Garapati, P V, 2008-12-16 11:12:19,
PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.,
Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
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Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
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3.1.3.48
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