Source:http://www.reactome.org/biopax/48887BiochemicalReaction2322
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Authored: Garapati, P V, 2008-12-16 11:12:19,
Edited: Garapati, P V, 2008-12-16 11:12:19,
Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33,
When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.
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Dephosphorylation of AKT by PP2A
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3.1.3.4
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