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Authored: Garapati, P V, 2008-12-16 11:12:19, Edited: Garapati, P V, 2008-12-16 11:12:19, Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33, Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
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Activation of Rac1 by pVav1
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