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Authored: Garapati, P V, 2008-12-16 11:12:19, Edited: Garapati, P V, 2008-12-16 11:12:19, PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB., Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
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CD28 bound PI3K phosphorylates PIP2 to PIP3
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2.7.1.153
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