Source:http://www.reactome.org/biopax/48887BiochemicalReaction2306
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Authored: Garapati, P V, 2008-12-16 11:12:19,
Edited: Garapati, P V, 2008-12-16 11:12:19,
Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33,
The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.
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Phosphorylation of CD28
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2.7.10
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