Source:http://www.reactome.org/biopax/48887BiochemicalReaction2278
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Authored: Akkerman, JW, 2009-06-03,
Edited: Jupe, S, 2009-11-03,
Reviewed: Harper, MT, 2009-11-02,
Reviewed: Jones, ML, 2009-11-02,
Reviewed: Poole, AW, 2009-11-02,
SLP-76 inducibly-associates with ADAP (also known as FYN-binding protein or SLAP-130) a hematopoietic-specific adapter protein. ADAP has been implicated in T cell migration and rearrangement of the actin cytoskeleton. In platelets, adhesion to fibrinogen stimulates the association of SLP-76 with ADAP and VASP (Obergfell et al. 2001). ADAP knockout mice exhibit mild thrombocytopenia (Kasirer-Friede et al. 2007).
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| biopax3:xref |
http://identifiers.org/pubmed/10671560,
http://identifiers.org/pubmed/10747096,
http://identifiers.org/pubmed/11113155,
http://identifiers.org/pubmed/11567141,
http://identifiers.org/pubmed/17003372,
http://identifiers.org/pubmed/9115214,
urn:biopax:UnificationXref:REACTOME DATABASE ID_430135,
urn:biopax:UnificationXref:REACTOME_REACT_20591_2
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p-SLP-76 binds ADAP
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