Source:http://www.reactome.org/biopax/48887BiochemicalReaction2277
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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PLC-gamma1 hydrolyses PIP2
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3.1.4.11
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