Source:http://www.reactome.org/biopax/48887BiochemicalReaction2273
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59,
Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.
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Phosphorylation of PLC-gamma1
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2.7.10
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