Source:http://www.reactome.org/biopax/48887BiochemicalReaction2269
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y112, Y128 and Y148. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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Phosphorylation of SLP-76
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2.7.10
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