Source:http://www.reactome.org/biopax/48887BiochemicalReaction2267
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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Recruitment of Gads to LAT
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