Source:http://www.reactome.org/biopax/48887BiochemicalReaction2266
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59,
The adaptor molecule LAT (Linker for the Activation of T cells) is a membrane protein that links the TCR signal to the cell activation. It has a total 10 (Y36, Y45, Y64, Y110, Y127, Y132, Y171, Y191, and Y226) conserved TBSMs (tyrosine based signaling motifs) in its cytoplasmic region. These tyrosine residues are phosphorylated by the activated ZAP-70 upon TCR/CD3 complex engagement. Phosphorylation of LAT creates binding sites for the Src homology 2 (SH2) domains of other proteins, including PLC-gamma1, Grb2 and Gads, and indirectly binds SOS, Vav, SLP-76, and Itk. The residues Y171, Y191 and Y226 are responsible for Grb2 binding, Y171 and Y191 but not Y226, are necessary for Gads binding and Y132 for the PLC-gamma1 binding.
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Phosphorylation of TBSMs in LAT
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2.7.10
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