Source:http://www.reactome.org/biopax/48887BiochemicalReaction2264
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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Phosphorylation of ZAP-70 by Lck
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2.7.10
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