Source:http://www.reactome.org/biopax/48887BiochemicalReaction2261
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Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59,
The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.
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Activation of Lck
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2.7.10
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