Source:http://www.reactome.org/biopax/48887BiochemicalReaction2243
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A proper assembly of repair complex may require displacement of Pol II from the damage site exposing a significant length of the corresponding template DNA with the lesions. Speculations on the mode of this displacement of Pol II are available from experimental evidences: a. CSB mediated dissociation of Pol II b. degradation of Pol II c. CSB mediated remodeling of damaged DNA-RNA PII interface etc.<BR>The TC-repair complex now consists of damaged DNA template: nascent mRNA hybrid. The damage site needs to be exposed to subsequent endonuclease activities.<BR>,
Authored: Gopinathrao, G, 2004-01-29 18:08:32
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Assembly of repair proteins at the site of Pol II blockage
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http://www.reactome.org/biopax/48887Complex177,
http://www.reactome.org/biopax/48887Complex2720,
http://www.reactome.org/biopax/48887Complex2724,
http://www.reactome.org/biopax/48887Protein1029,
http://www.reactome.org/biopax/48887Protein8120,
http://www.reactome.org/biopax/48887Protein8124,
http://www.reactome.org/biopax/48887Protein8125,
http://www.reactome.org/biopax/48887Protein926
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