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Authored: Matthews, L, 2003-09-07 08:47:00, DNA-PKcs is recruited to the Ku-DNA end complex (Gottlieb and Jackson, 1993), causing Ku to translocate inwards (away from the break) approximately 10 bp (Yoo and Dynan, 1999). This forms the DNA-PK complex (DNA-PKcs plus Ku70/Ku80) at each end of the DNA double strand break.
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Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks
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