Source:http://www.reactome.org/biopax/48887BiochemicalReaction2207
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Authored: Matthews, L, 2003-08-11 05:43:00,
In order for repair of the double-strand break to occur, the 5' ends of the break must first be resected to produce single-strands that invade homologous duplex DNA. Although the enzymatic activities responsible for end-processing in humans are not known with certainty, the MRE11-RAD50-NBS1 (MRN) complex has been implicated in this process (Thompson and Schild, 2001). The MRN complex may function as a bridge between double-strand break ends through interactions between the coiled-coil domains of RAD50 (Hoptner et al., 2002).
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http://identifiers.org/pubmed/11139606,
http://identifiers.org/pubmed/11376695,
http://identifiers.org/pubmed/12152085,
http://identifiers.org/pubmed/9705271,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0000729,
urn:biopax:UnificationXref:REACTOME DATABASE ID_83897,
urn:biopax:UnificationXref:REACTOME_REACT_172_2
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Resection of double-strand break ends
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