Source:http://www.reactome.org/biopax/48887BiochemicalReaction2198
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ATM mediated phosphorylation of MDC1/NFBD1 may be involved in the rapid relocalization of MDC1/NFBD1 to nuclear foci that contain the MRE11 complex, phosphorylated histone H2AX and 53BP1 (Goldberg et al., 2003). NFBD1 may also function in recruiting DNA checkpoint signaling and repair proteins to the sites of DNA damage (Xu and Stern., 2003 and Stewart et al.,2003).,
Authored: Matthews, L, 2003-11-18 00:00:00
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Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains)
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