Source:http://www.reactome.org/biopax/48887BiochemicalReaction2097
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Authored: Garapati, P V, 2009-02-12 18:17:40,
Edited: Garapati, P V, 2009-02-12 18:17:40,
Reviewed: Barclay, AN, 2010-05-20,
SIRP beta is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids lacking the signaling motifs for association with phosphatases. Instead, SIRP beta binds with a dimeric protein DNAX activation protein 12 (DAP12) to transmit activating signals. DAP12 contains an ITAM motif and can associate with a basic amino acid in SIRP beta's transmembrane region.
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Interaction of DAP12 and SIRP beta
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