Source:http://www.reactome.org/biopax/48887BiochemicalReaction1984
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Authored: Dall'Olio, GM, 2009-11-10,
Edited: Jassal, B, 2009-11-10,
Reviewed: Gagneux, P, 2010-04-16,
The last mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen, uses Dolichyl phosphate D-mannose as the mannose donor, and is catalyzed by ALG9. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 was thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006).
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Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen.
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