Source:http://www.reactome.org/biopax/48887BiochemicalReaction1983
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Authored: Dall'Olio, GM, 2009-11-10,
Edited: Jassal, B, 2009-11-10,
Reviewed: Gagneux, P, 2010-04-16,
The eighth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses dolichyl phosphate D-mannose as a mannose donor. Defects in ALG12 are the cause of congenital disorder of glycosylation type 1G (CDG1G) (Chantret I et al, 2002).
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Addition of the eighth mannose to the N-glycan precursor by ALG12, inside the ER lumen
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