Source:http://www.reactome.org/biopax/48887BiochemicalReaction1978
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A third mannose is added to the N-glycan precursor by ALG2 using its alpha1,6-mannosyltransferase activity. This has been demonstrated experimentally in yeast (O'Reilly MK et al, 2006; Kämpf M et al, 2009); the human reaction is inferred by homology. Defects in ALG2 are the cause for CDG1I (Thiel C et al, 2003).,
Authored: Dall'Olio, GM, 2009-11-10,
Edited: Jassal, B, 2009-12-07,
Reviewed: Gagneux, P, 2010-04-16
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Addition of a third mannose to the N-glycan precursor by ALG2
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