Source:http://www.reactome.org/biopax/48887BiochemicalReaction1974
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Authored: Dall'Olio, GM, 2009-11-10,
Edited: Jassal, B, 2009-11-10,
In the first step of N-glycan precursor (LLO) synthesis, N-acetylglucosamine is added, via an alpha-1,3 linkage, to a molecule of dolichyl phosphate, producing N-acetyl-D-glucosaminyl-diphosphodolichol (Eckert V et al, 1998). This reaction is catalyzed by DPAGT1 (ALG7 in yeast), mutations in which are associated with CDG disorder type I-J (Wu X et al, 2003). The dolichyl phosphate acts as an anchor for the LLO, so the following sugar-addition reactions take place on a sugar anchored in the ER membrane.,
Reviewed: Gagneux, P, 2010-04-16
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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate
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2.7.8.15
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