Source:http://www.reactome.org/biopax/48887BiochemicalReaction1882
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Authored: May, B, 2011-03-18,
Edited: May, B, 2011-03-18,
HIF1AN (FIH, FIH-1) catalyzes the hydroxylation of an asparagine residue on each of HIF1A and HIF2A (Hewitson et al. 2002, Lando et al. 2002, Metzen et al. 2003, Lancaster et al. 2004). The reaction requires molecular oxygen as a substrate and is therefore inhibited by hypoxia.,
Reviewed: Rantanen, Krista, 2012-05-19
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Cytosolic Hydroxylation of Asparagine Residue in HIF alpha
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1.14.11
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