Source:http://www.reactome.org/biopax/48887BiochemicalReaction1865
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Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established.,
Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Reviewed: Ezzat, S, 2012-05-15
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| biopax3:xref |
http://identifiers.org/pubmed/10652257,
http://identifiers.org/pubmed/10918587,
http://identifiers.org/pubmed/16091734,
http://identifiers.org/pubmed/16844695,
http://identifiers.org/pubmed/18337450,
http://identifiers.org/pubmed/19147536,
http://identifiers.org/pubmed/19749790,
urn:biopax:UnificationXref:REACTOME DATABASE ID_2077380,
urn:biopax:UnificationXref:REACTOME_REACT_121127_1
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Activated FGFR mutants bind PLC-gamma
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