Source:http://www.reactome.org/biopax/48887BiochemicalReaction1864
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Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).,
Reviewed: Ezzat, S, 2012-05-15
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| biopax3:xref |
http://identifiers.org/pubmed/11689702,
http://identifiers.org/pubmed/11739186,
http://identifiers.org/pubmed/14534538,
http://identifiers.org/pubmed/15448205,
http://identifiers.org/pubmed/17505008,
http://identifiers.org/pubmed/18381441,
http://identifiers.org/pubmed/18757403,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1986647,
urn:biopax:UnificationXref:REACTOME_REACT_121187_1
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Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants
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