Source:http://www.reactome.org/biopax/48887BiochemicalReaction1861
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| rdf:type | |
| biopax3:comment |
Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011).,
Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Reviewed: Ezzat, S, 2012-05-15
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| biopax3:xref |
http://identifiers.org/pubmed/11157491,
http://identifiers.org/pubmed/11429702,
http://identifiers.org/pubmed/18381441,
http://identifiers.org/pubmed/18757403,
http://identifiers.org/pubmed/19103595,
http://identifiers.org/pubmed/19946327,
http://identifiers.org/pubmed/20179196,
http://identifiers.org/pubmed/21160078,
http://identifiers.org/pubmed/21666749,
http://identifiers.org/pubmed/21711248,
http://identifiers.org/pubmed/9857065,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1982085,
urn:biopax:UnificationXref:REACTOME_REACT_120761_1
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| biopax3:dataSource | |
| biopax3:displayName |
Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants
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| biopax3:right |