Source:http://www.reactome.org/biopax/48887BiochemicalReaction1860
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Activation of FGFR mutants has in some cases been shown to result in phosphorylation of both FRS2alpha and ERK1/2, suggesting activation of the MAPK pathway through wild-type like recruitment of the GRB2-SOS1 complex (reviewed in Wesche, 2011; see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Hart, 2000).,
Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Reviewed: Ezzat, S, 2012-05-15
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| biopax3:xref |
http://identifiers.org/pubmed/10918587,
http://identifiers.org/pubmed/21160078,
http://identifiers.org/pubmed/21666749,
http://identifiers.org/pubmed/21711248,
http://identifiers.org/pubmed/9857065,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1982082,
urn:biopax:UnificationXref:REACTOME_REACT_120735_1
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| biopax3:dataSource | |
| biopax3:displayName |
GRB2-SOS1 is recruited by activated FGFR mutants
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