Source:http://www.reactome.org/biopax/48887BiochemicalReaction1854
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Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Expression of the FGFR4 Y367C mutant in MDA-MB453 breast cancer cell line results in constitutive tyrosine phosphorylation of the receptor and serum-independent activation of downstream signaling as monitored by Erk phosphorylation. Ectopic expression of FGFR4 Y367C in HEK cells also leads to Erk activation and enhanced cellular proliferation. Akt and phospho-AKT levels were not affected by overexpression of the FGFR4 Y367C mutant, however (Roidl, 2010),
Reviewed: Ezzat, S, 2012-05-15
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Autocatalytic phosphorylation of FGFR4 Y367C mutant
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2.7.10
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