Source:http://www.reactome.org/biopax/48887BiochemicalReaction1825
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000).,
Reviewed: Ezzat, S, 2012-05-15
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
|
| biopax3:eCNumber |
2.7.10
|
| biopax3:left | |
| biopax3:right |