Source:http://www.reactome.org/biopax/48887BiochemicalReaction1817
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Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).,
Reviewed: Ezzat, S, 2012-05-15
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FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
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