Source:http://www.reactome.org/biopax/48887BiochemicalReaction1812
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Guasch, 2001; Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1 and ZMYM2-FGFR1, mutation of the PLCgamma binding site significantly decreased the transformative phenotype of the FGFR1 fusion (Roumiantsev, 2004).,
Reviewed: Ezzat, S, 2012-05-15
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
FGFR1 fusions bind PLCgamma
|
| biopax3:left | |
| biopax3:right |