Source:http://www.reactome.org/biopax/48887BiochemicalReaction1811
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Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
In a murine mouse model of ZNF198-FGFR1-induced EMS, treatment with the FGFR-inhibitor Midostaurin (PKC412) resulted in prolonged survival (Chen, 2004). Similarly, growth of ZNF-198-FGFR1-, FGFR1OP2-FGFR1-, and BCR-FGFR1-expressing lines is blocked by treatment with FGFR-inhibitors (Demiroglu, 2001; Gu, 2006; Chase, 2007; Zhen, 2007; Wasag, 2011).,
Reviewed: Ezzat, S, 2012-05-15
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http://identifiers.org/pubmed/11739186,
http://identifiers.org/pubmed/15448205,
http://identifiers.org/pubmed/16946300,
http://identifiers.org/pubmed/17533378,
http://identifiers.org/pubmed/17698633,
http://identifiers.org/pubmed/21330321,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1839039,
urn:biopax:UnificationXref:REACTOME_REACT_120841_1
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Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
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