Source:http://www.reactome.org/biopax/48887BiochemicalReaction1807
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Authored: Rothfels, K, 2012-02-09,
Edited: Rothfels, K, 2012-05-16,
FGFR1-amplified lung cancer and breast cancer cells show strong phosphorylation of FGFR1 and do not show elevated levels of FGF ligand, suggesting that these receptors can undergo ligand-independent activation. Phosphorylation is enhanced in the presence of exogenous ligand, supporting the notion that overexpressed FGFR1 can be activated by both ligand- and ligand-independent pathways (Koziczak, 2004; Dutt, 2008; Weiss, 2010). The biochemical consequences of overexpression of FGFR1 in other cancer types remain to be determined (reviewed in Turner and Gross, 2010; Wesche, 2011.,
Reviewed: Ezzat, S, 2012-05-15
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http://identifiers.org/pubmed/15116089,
http://identifiers.org/pubmed/20094046,
http://identifiers.org/pubmed/21160078,
http://identifiers.org/pubmed/21666749,
http://identifiers.org/pubmed/21711248,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1982066,
urn:biopax:UnificationXref:REACTOME_REACT_120931_1
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Ligand-independent phosphorylation of overexpressed FGFR1
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2.7.10
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