Source:http://www.reactome.org/biopax/48887BiochemicalReaction18
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Authored: May, B, 2009-07-22,
Edited: May, B, 2009-07-22,
Reviewed: Wilusz, J, 2009-09-17,
The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.
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| biopax3:xref |
http://identifiers.org/pubmed/11283721,
http://identifiers.org/pubmed/14749774,
http://identifiers.org/pubmed/15231747,
http://identifiers.org/pubmed/15475613,
http://identifiers.org/pubmed/15711010,
http://identifiers.org/pubmed/16051491,
http://identifiers.org/pubmed/16141059,
http://identifiers.org/pubmed/17245413,
http://identifiers.org/pubmed/19239894,
http://identifiers.org/pubmed/19279404,
urn:biopax:UnificationXref:REACTOME DATABASE ID_429978,
urn:biopax:UnificationXref:REACTOME_REACT_20540_1
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Binding of Lsm1-7 Complex to Deadenylated mRNA
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