Source:http://www.reactome.org/biopax/48887BiochemicalReaction1796
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Authored: Rothfels, K, 2011-08-15,
Reviewed: Gotoh, N, 2011-08-26,
The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.
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SPRY2 binds CBL
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