Source:http://www.reactome.org/biopax/48887BiochemicalReaction1789
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Authored: Rothfels, K, 2011-08-15,
FRS2alpha has 8 canonical MAPK phosphorylation sites which are phosphorylated by activated ERK1/2 after FGF stimulation. Phosphorylation of these 8 threonine residues counteracts the activating effect of tyrosine phosphorylation of FRS2alpha, although the exact mechanism for this negative regulation is not known. Expression of a version of FRS2alpha in which the 8 threonine residues are mutated to valine results in enhanced tyrosine phosphorylation of FRS2alpha, enhanced GRB2-SOS1 recruitment and a more sustained MAPK response. The 8 threonine residues are not conserved in FRS2beta; as a result, signaling through FRS2beta complexes do not appear to be subject to this downregulation.,
Reviewed: Gotoh, N, 2011-08-26
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Activated ERK1/2 threonine-phosphorylate FRS2alpha.
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2.7.11.24
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