Source:http://www.reactome.org/biopax/48887BiochemicalReaction1781
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Authored: Rothfels, K, 2011-08-15,
Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.,
Reviewed: Gotoh, N, 2011-08-26
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GRB2:SOS1 is recruited to activated FGFR through p-SHC1
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